Rebecca (Reba) J Howard, PhD
Senior Researcher in Biochemistry
Stockholm University
Department of Biochemistry & Biophysics
Platform Coordination Officer
KTH Royal Institute of Technology
Department of Applied Physics
Email: rebecca.howard@scilifelab.se
CV & Publications: rebahoward.net
Selected Publications
- Fan C°, Lycksell M, Zhuang Y, Howard RJ°, Lindahl E°. Calcium stabilizes the flexible N-terminal domain of the bacterial ion channel DeCLIC (2025) Journal of Structural Biology X 12: 100139.
- Fan C°, Cowgill J, Howard RJ°, Lindahl E°. Cryo-EM structures of ρ1 GABA(A) receptors with antagonist and agonist drugs (2025) Nature Communications 16(1): 7077.
- Karlsson E, Andén O, Fan C, Fourati Z, Haouz A, Zhuang Y, Howard RJ°, Delarue M°, Lindahl E°. Vestibular modulation by stimulant derivatives in a pentameric ligand-gated ion channel (2025) British Journal of Pharmacology 182(12): 2790–2802.
- Haloi N, Karlsson E, Delarue M, Howard RJ°, Lindahl E°. Discovering cryptic pocket opening and binding of a stimulant derivative in a vestibular site of the 5-HT(3A) receptor (2025) Science Advances 11(15): eadr0797.
- Fan C*, Cowgill J*, Howard RJ°, Lindahl E°. Divergent mechanisms of steroid inhibition in the human ρ1 GABA(A) receptor (2024) Nature Communications 15(1): 7795.
- Cowgill J*, Fan C*, Haloi N, Tobiasson V, Zhuang Y, Howard RJ°, Lindahl E°. Structure and dynamics of differential ligand binding in the human ρ-type GABA(A) receptor (2023) Neuron 11(21): p3450-3464.e5.
- Lycksell M*, Rovšnik U*, Hanke A, Martel A, Howard RJ, Lindahl E. Biophysical characterization of calcium-binding and modulatory-domain dynamics in a pentameric ligand-gated ion channel (2022) Proceedings of the National Academy of Sciences of the USA 119(50): e2210669119.
- Zhuang Y, Noviello CM, Hibbs RE, Howard RJ, Lindahl E. Differential interactions of resting, activated, and desensitized states of the α7 nicotinic acetylcholine receptor with lipidic modulators (2022) Proceedings of the National Academy of Sciences of the USA 119(43): e2208081119.
- Sridhar A*, Lummis SCR*, Pasini D, Mehregan A, Brams M, Kambara K, Bertrand D, Lindahl E, Howard RJ°, Ulens C°. Regulation of a pentameric ligand-gated ion channel by a semi-conserved cationic-lipid binding site (2021) Journal of Biological Chemistry 297(2): 100899.
- Howard RJ. Elephants in the dark: insights and incongruities in pentameric ligand-gated ion channel models. Journal of Molecular Biology (2021) 433(17): 167128.
- Carnevale V*°, Delemotte L*°, Howard RJ*°. Molecular dynamics simulations of ion channels (2021) Trends in Biochemical Sciences 46(7): 621–622.
- Howard RJ. Too much of a good thing: Evolving our relationship with alcohol (2014) TedX Skidmore College.
* Equal contributions
° Co-corresponding authors
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